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CD200 Receptor Mouse anti-Human, PerCP-eFluor 710, Clone: OX108, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-9201-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15579406

  • £208.18 / 100 tests


Estimated Shipment date
from Supplier 28-06-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The monoclonal antibody OX108 recognizes human CD200R also known as OX2. CD200R is an inhibitory receptor with a similar structure as its ligand, CD200, yet lacks an ITIM domain typically found in inhibitory receptors. Instead the CD200R cytoplasmic domain contains a novel phosphotyrosine binding domain, NPXY, which after binding SHIP inhibits ERK, JNK and MAPK p38 pathways. In activated macrophages signaling results in inhibition of TNFα secretion. Isoforms of CD200R have been identified and are thought to play a major role in differentiation, especially in regards to tolerogenic DCs.

Expression is restricted to hematopoietic cells: myeloid cells (monocytes, macrophages, DCs, neutrophils, mast cells and basophils) and a subset of T lymphocytes as well as langerhans (LC) cells and dendritic epidermal T cells. The epitope of OX108 is thought to be near the binding site of CD200.
Description & Specifications

Specifications

CD200 Receptor
OX108
PerCP-eFluor 710
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
IgG1
RUO
Primary
Human
Flow Cytometry
5μL (0.5μg)/test
Conjugated
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal