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CD200 Receptor Mouse anti-Human, Clone: OX108, eBioscience™

Mouse Monoclonal Antibody

Marca:  Affymetrix eBioscience 14-9201-80

UNSPSC : 12352200

Code : Z2

Detalles adicionales : Weight : 0.01000kg

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Código de producto. 15258157

  • £36.08 / 25µg


Estimated Shipment
03-08-2017
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Exención de responsabilidad:

For Research Use Only.


Especificaciones

Descripción

The monoclonal antibody OX108 recognizes human CD200R also known as OX2. CD200R is an inhibitory receptor with a similar structure as its ligand, CD200, yet lacks an ITIM domain typically found in inhibitory receptors. Instead the CD200R cytoplasmic domain contains a novel phosphotyrosine binding domain, NPXY, which after binding SHIP inhibits ERK, JNK and MAPK p38 pathways. In activated macrophages signaling results in inhibition of TNFα secretion. Isoforms of CD200R have been identified and are thought to play a major role in differentiation, especially in regards to tolerogenic DCs.

Expression is restricted to hematopoietic cells: myeloid cells (monocytes, macrophages, DCs, neutrophils, mast cells and basophils) and a subset of T lymphocytes as well as langerhans (LC) cells and dendritic epidermal T cells. The epitope of OX108 is thought to be near the binding site of CD200.
Descripción & Especificaciones

Especificaciones

CD200 Receptor
OX108
Unlabeled
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
IgG1
RUO
Primary
Human
Flow Cytometry
0.5mg/mL
Purified
Murine
25μg
Store at 2-8°C.
Monoclonal