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CD20 Rat anti-Mouse, PE, Clone: QCH6A7, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-0203-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15576726

  • £176.70 / 100µg


EU Stock 1
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Disclaimers:

For Research Use Only.


Description

Description

The monoclonal antibody QCH6A7 reacts with mouse CD20. CD20 is a B cell specific, 32kDa membrane protein that is expressed on late pro-B cells through memory B cells in the B cell lineage. CD20 is not found on hematopoietic stem cells, early pro-B cells or later mature plasma cells. CD20 is involved in intracellular calcium regulation and plays a role in B cell proliferation. CD20 is intially expressed after the induction of CD19 during development and is coexpressed with IgM during the pre-B to immature B cell transition in bone marrow. Expression of CD20 increases during maturation with almost all mature B cells expressing some level of CD20. Unlike other B cell antigens, CD20 is not shed or internalized upon antibody binding. Monoclonal antibodies against the CD20 antigen may be used to deplete B cells and CD20 has proven to be an effective immunotheraputic target in B cell lymphomas and several autoimmune diseases including rheumatoid arthritis and type I diabetes. CD20 consists of 4 transmembrane domains and a 44 amino acid extracellular domain which contains the QCH6A7 epitope.

Staining with clone QCH6A7 provides significantly improved staining intensity compared to clone AISB12 in flow cytometric assays.
Specifications

Specifications

CD20
QCH6A7
PE
Conjugated
Rat
100μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Ms4a1, Ly-44
IgG2a
RUO
Primary
Murine
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