missing translation for 'onlineSavingsMsg'
Learn More

CD20 Monoclonal Antibody (L26), eFluor™ 660, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 50-0202-80

64.66 GBP valid until 2024-03-29
Use promo code "21615" to get your promotional price.



Code : Z2

Additional Details : Weight : 0.25000kg

Product Code. 15391850

  • £97.00 / 25µg
Estimated Shipment: 07-05-2024
to see stock.

Please to purchase this item. Need a web account? Register with us today!


Description

Description

CD20 is a cell surface 33-37 (depending on the degree of phosphorylation)kDa non-glycosylated surface phosphoprotein expressed on mature and most malignant B cells, but not stem cells or plasma cells (low number of the CD20 has been also detected on a subpopulation of T lymphocytes and it can be expressed on follicular dendritic cells). Its expression on B cells is synchronous with the expression of surface IgM. CD20 regulates transmembrane calcium conductance (probably functioning as a component of store-operated calcium channel), cell cycle progression and B-cell proliferation. It is associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change and/or BCR (B cell antigen receptor) aggregation. After the receptor ligation, BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface. CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following mAb treatment.

CD20 Monoclonal antibody specifically detects CD20 in Cynomolgus Monkey, Human, Rhesus Monkey samples. It is validated for Immunocytochemistry, Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot.
Specifications

Specifications

CD20
Monoclonal
0.2 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P11836
Ms4a1
Affinity chromatography
RUO
102118491, 696843, 931
4° C, store in dark, DO NOT FREEZE!
Liquid
Immunocytochemistry, Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot
L26
eFluor 660
Ms4a1
AA960661; APY; ATOPY; B1; B-cell differentiation antigen Ly-44; B-lymphocyte antigen CD20; B-lymphocyte cell-surface antigen B1; B-lymphocyte surface antigen B1; Bp35; Cd20; CD20 antigen; CD20 cell surface protein; CD20 receptor; CVID5; EGK_06167; Fc epsilon receptor I beta chain; Fc Fragment of IgE high affinity I receptor for beta polypeptide; FCER1B; High affinity immunoglobulin epsilon receptor subunit beta; IgE Fc receptor subunit beta; IGEL; IGER; IGHER; LEU16; LEU-16; Leukocyte surface antigen Leu-16; Ly44; Ly-44; Lymphocyte antigen 44; membrane spanning 4-domains A1; membrane-spanning 4-domains subfamily A member 1; membrane-spanning 4-domains, subfamily A, member 1; membrane-spanning 4-domains, subfamily A, member 2; MGC3969; MS4A1; MS4A2; S7
Mouse
25 μg
Primary
Cynomolgus Monkey, Human, Rhesus Monkey
Antibody
IgG2a κ
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Certificates
Special Offers

Special Offers

For Research Use Only.