CD20 Mouse anti-Human, Clone: L26, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-0202-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15246847

Quantity Price
1 £ 48.31 / 25µg
Estimated Shipment date
from Supplier 04-04-2017
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Description and Specification

Specification

Gene Alias B1, MS4A2, Leu-16
Quantity 25μg
Format Purified
Conjugate Unlabeled
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Applications Western Blotting
Clone L26
Concentration 0.5mg/mL
Primary or Secondary Primary
Isotype IgG2a
Regulatory Status RUO
Storage Requirements Store at 2-8°C.
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Antigen CD20
Monoclonal or Polyclonal Monoclonal
Species Reactivity Cynomolgus, Human, Rhesus Ma
Host Species Mouse

The monoclonal antibody L26 recognizes human CD20, a two transmembrane spanning protein found on precursor and mature B lymphocytes. Expression is lost upon differentiation to plasma cells. The levels of CD20 are critical in evaluating malignant B lymphocytes including Non-Hodgkin’s Lymphoma, and Acute B cell, Chronic Lymphocytic and Hairy-Cell Leukemias. CD20 plays a role in B cell differentiation and activation. The structure of the protein shows a small extracellular loop with the carboxy and amino termini in the cytoplasmic compartment. The L26 antibody recognizes an epitope in the cytoplasmic domain and therefore requires permeabilization of the tissue for staining applications. Unlike many anti-CD20 antibodies that recognize the extracellular domain, the epitope recognized by L26 will not be blocked by therapeutic antibodies to CD20, like Rituximab.