CD20 Mouse anti-Human, Alexa Fluor 488, Clone: L26, eBioscience™

Mouse Monoclonal Antibody

Brand: Affymetrix eBioscience

Manufacturer Part Number: 53-0202-82


UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg

Disclaimers: For Research Use Only.

Product Code. 15311990

Quantity Price
1 £163.00 / 100µg
Estimated Shipment date
from Supplier 27-10-2016
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Description and Specification


Antigen CD20
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Immunohistochemistry (Frozen)
Clone L26
Concentration 0.5mg/mL
Conjugate Alexa Fluor 488
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias B1, MS4A2, Leu-16
Host Species Mouse
Isotype IgG2a
Quantity 100μg
Regulatory Status RUO
Species Reactivity Cynomolgus, Human, Rhesus Ma
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

The monoclonal antibody L26 recognizes human CD20, a two transmembrane spanning protein found on precursor and mature B lymphocytes. Expression is lost upon differentiation to plasma cells. The levels of CD20 are critical in evaluating malignant B lymphocytes including Non-Hodgkin’s Lymphoma, and Acute B cell, Chronic Lymphocytic and Hairy-Cell Leukemias. CD20 plays a role in B cell differentiation and activation. The structure of the protein shows a small extracellular loop with the carboxy and amino termini in the cytoplasmic compartment. The L26 antibody recognizes an epitope in the cytoplasmic domain and therefore requires permeabilization of the tissue for staining applications. Unlike many anti-CD20 antibodies that recognize the extracellular domain, the epitope recognized by L26 will not be blocked by therapeutic antibodies to CD20, like Rituximab.