CD1d Mouse anti-Human, APC, Clone: 51.1, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-0016-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15547846

Quantity Price
1 £ 66.65 / 25 tests
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Primary or Secondary Primary
Clone 51.1
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Quantity 25 tests
Antigen CD1d
Concentration 5μL (0.125μg)/test
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Applications Flow Cytometry
Isotype IgG2b
Gene Alias R3, R3G1
Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Conjugate APC
Host Species Mouse
Species Reactivity Human

The monoclonal antibody 51.1 reacts with human CD1d, a member of the CD1 family with similarity to the non-polymorphic MHC Class I-like molecules. CD1d is a highly conserved single transmembrane receptor of the Immunoglobulin Superfamily. CD1d can associate with beta-microglobulin another feature showing similarity to MHC class I molecules, but can also exist as a nonglycosylated protein not in association with beta microglobulin. This suggests different control mechanisms for presenting glycolipid containing molecules to CD1d reactive NKT cells. Expression of CD1d is found on B cells of the periphery, in resting monocytes and cortical thymocytes. On intestinal epithelial cells (IEC) expression is polarized. Expression can also be found at low levels intracellularly in hepatocytes. In HCV (hepatitis C virus) livers, CD1d is highly expressed compared to normal controls.

The 51.1 monoclonal antibody has been shown to have functional activity; blocking the interaction of CD1d transfected cells with NKT cells.