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CD197 (CCR7) Monoclonal Antibody (4B12), APC, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

£157.00 - £249.00

Specifications

Antigen CD197 (CCR7)
Clone 4B12
Concentration 0.2 mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15330700
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Affymetrix eBioscience
17-1971-81
50 μg
£157.00
50µg
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Estimated Shipment: 04-04-2024
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15340700
View Documents Promotion Details
Affymetrix eBioscience
17-1971-82
100 μg
£249.00
100µg
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Estimated Shipment: 26-03-2024
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Description

Description

Description: The 4B12 monoclonal antibody reacts with mouse CCR7, also known as EBI-1 and CD197. CCR7 is a chemokine receptor for the chemokines CCL19 (CKβ11, ELC, MIP3β, Scya19, Exodus-3) and CCL21 (CKβ9, SLC, MIP2β, Scya21, Exodus-2). In recent years, the role of chemokines in directing the migration of lymphocytes has been well-characterized. One of the most important mediators of homeostatic trafficking of naive T cells to secondary lymphoid organs (SLO) is the chemokine receptor CCR7. Binding of its ligands, CCL19 and CCL21, mediates the trans endothelial migration of T cells across high endothelial venules into SLO. It has also been demonstrated that CCR7 plays a role in the localization of dendritic cells and B cells during an immune response. CCR7 is a chemokine receptor for the chemokines CCL19 (CKβ11, ELC, MIP3β, Scya19, Exodus-3) and CCL21 (CKβ9, SLC, MIP2β, Scya21, Exodus-2). In addition to its significant role in the chemotaxis of lymphocytes, human CCR7 has also been recognized as a marker for a distinct subset of memory T cells, the central memory (TCM) population. These cells are characterized by the expression of CCR7 and CD62L and reside within peripheral lymphoid organs. CCR7 also plays a role in thymocyte development and its deficiency leads to disturbed thymic architecture, aberrant T cell development, and limited thymocyte expansion.

CD197 (CCR7) Monoclonal antibody specifically detects CD197 (CCR7) in Mouse samples. It is validated for Flow Cytometry.
Specifications

Specifications

CD197 (CCR7)
0.2 mg/mL
Monoclonal
Liquid
RUO
P47774
Ccr7
Primary
4° C, store in dark, DO NOT FREEZE!
Ccr7
4B12
Flow Cytometry
APC
Rat
Mouse
12775
IgG2a κ
Affinity chromatography
Antibody
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