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CD197 (CCR7) Monoclonal Antibody (4B12), Alexa Fluor™ 700, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
£249.00
Specifications
Antigen | CD197 (CCR7) |
---|---|
Clone | 4B12 |
Concentration | 0.2 mg/mL |
Applications | Flow Cytometry |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15312140
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Affymetrix eBioscience
56-1971-82 |
100 μg |
£249.00
100µg |
Estimated Shipment: 09-04-2024 Log in to see stock. |
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Description
Description: The 4B12 monoclonal antibody reacts with mouse CCR7, also known as EBI-1 and CD197. CCR7 is a chemokine receptor for the chemokines CCL19 (CKβ11, ELC, MIP3β, Scya19, Exodus-3) and CCL21 (CKβ9, SLC, MIP2β, Scya21, Exodus-2). In recent years, the role of chemokines in directing the migration of lymphocytes has been well-characterized. One of the most important mediators of homeostatic trafficking of naive T cells to secondary lymphoid organs (SLO) is the chemokine receptor CCR7. Binding of its ligands, CCL19 and CCL21, mediates the trans endothelial migration of T cells across high endothelial venules into SLO. It has also been demonstrated that CCR7 plays a role in the localization of dendritic cells and B cells during an immune response. CCR7 is a chemokine receptor for the chemokines CCL19 (CKβ11, ELC, MIP3β, Scya19, Exodus-3) and CCL21 (CKβ9, SLC, MIP2β, Scya21, Exodus-2). In addition to its significant role in the chemotaxis of lymphocytes, human CCR7 has also been recognized as a marker for a distinct subset of memory T cells, the central memory (TCM) population. These cells are characterized by the expression of CCR7 and CD62L and reside within peripheral lymphoid organs. CCR7 also plays a role in thymocyte development and its deficiency leads to disturbed thymic architecture, aberrant T cell development, and limited thymocyte expansion.
CD197 (CCR7) Monoclonal antibody specifically detects CD197 (CCR7) in Mouse samples. It is validated for Flow Cytometry.Specifications
CD197 (CCR7) | |
0.2 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
P47774 | |
Ccr7 | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
Ccr7 |
4B12 | |
Flow Cytometry | |
Alexa Fluor 700 | |
Rat | |
Mouse | |
12775 | |
IgG2a κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.