CD197 (CCR7) Rat anti-Human, APC, Clone: 3D12, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-1979-41

25RXN Anit-H CD197 (CCR7) APC 25 Tests

Code: NEW

Additional Details:
Additional Details: Weight: 0.00100kg



Disclaimers: For Research Use Only.

Product Code. 15547065

Quantity Price
1 £ 120.2 / 25 reactions
Estimated Shipment date
from Supplier 24-02-2017
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Description and Specification

Specification

Gene Alias EBI-1, MIP-3 beta Receptor
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Conjugate APC
Antigen CD197 (CCR7)
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Host Species Rat
Applications Flow Cytometry
Isotype IgG2a
Quantity 25 tests
Regulatory Status RUO
Species Reactivity Human
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Clone 3D12
Concentration 5μL (0.125μg)/test

The 3D12 monoclonal antibody reacts with human CCR7, also known as EBI-1 and CD197. CCR7 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains and functions as a receptor for 6Ckine/SLC (secondary lymphoid-tissue chemokine), CCL19 and CCL21. CCR7 has been shown to be internalized via clathrin-coated pits and the majority recycled back to the plasma membrane. CCR7 is expressed on T cells and can be used to distinguish populations of naïve from central and effector memory T cells. CCR7 has been shown to play a role in migration of memory T cells to inflamed tissue. Expression of CCR7 is also found on DC’s. During DC maturation CCR7 expression increases and is thought to be involved in a variety of functions: chemotaxis to the lymph node, cellular architecture, rate of endocytosis, survival and maturation. Expression of CCR7 on the cell surface can be down regulated upon ligand binding.