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CD196 (CCR6) Monoclonal Antibody (R6H1), FITC, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

£76.00 - £203.00

Specifications

Antigen CD196 (CCR6)
Clone R6H1
Concentration 5 μL/Test
Applications Flow Cytometry
Classification Monoclonal
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Product Code Brand Quantity Price Quantity & Availability  
15596506
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Affymetrix eBioscience
11-1969-42
100 Tests
£203.00
100 tests
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15586506
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Affymetrix eBioscience
11-1969-41
25 Tests This item is currently unavailable or has been discontinued.
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Description

Description

Description: This R6H1 monoclonal antibody reacts with CD196 (also known as CCR6), a seven transmembrane G protein-coupled receptor expressed on T, B, dendritic, natural killer, and Langerhans cells. This CC chemokine receptor uniquely binds MIP-3a/CCL20, a chemoattractant for dendritic cells, effector/memory T cells, and B cells. CD196 is also involved in host defense and inflammation at epithelial sites. Furthermore, this receptor has been implicated in Th17 differentiation and CD4+FoxP3+ regulatory T cell development. Applications Reported: This R6H1 antibody has been reported for use in flow cytometric analysis. Applications Tested: This R6H1 antibody has been pre-titrated and tested by flow cytometric analysis on normal human peripheral blood cells. This can be used at 5 μL (0.5 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered.

CCR6 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.
Specifications

Specifications

CD196 (CCR6)
5 μL/Test
Monoclonal
Liquid
RUO
P51684
CCR6
Primary
4° C, store in dark, DO NOT FREEZE!
CCR6
R6H1
Flow Cytometry
FITC
Mouse
Human
1235
IgG1 κ
Affinity chromatography
Antibody
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