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CD194 (CCR4) Mouse anti-Human, PerCP-eFluor 710, Clone: D8SEE, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-1949-42

Code : NEW

Additional Details : Weight : 0.23750kg

 View more versions of this product

Product Code. 15599206

  • £220.84 / 100 tests


Estimated Shipment date
from Supplier 30-10-2017
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Disclaimers:

For Research Use Only.


Description

Description

This D8SEE monoclonal antibody reacts with human CD194 (CCR4). CD194, also known as C-C Chemokine Receptor 4 (CCR4) is a member of the G protein-coupled receptor family, a large family characterized by seven transmembrane alpha helical domains. The ligands for CCR4 are CCL17 (TARC) and CCL22 (MDC), which direct the migration of target cells. CCR4 and its ligands, along with the other receptors CCR10 and CLA, are particularly important for the recruitment of T cells into the skin, where they may also play a role in adhesion and extravasation. Although CCR4 expression was originally believed to be restricted to Th2 cells, it has since been observed in some subsets of Th17, Treg, and Th1 cells. It is not expressed by naïve T cells, indicating a role in memory or effector function. Other cells that express CCR4 are activated NK cells, platelets, monocytes, and basophils.
Specifications

Specifications

CD194 (CCR4)
D8SEE
PerCP-eFluor™ 710
Conjugated
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Monoclonal
Flow Cytometry
5μL (0.125μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
C-C Motif Chemokine Receptor 4
IgG1
RUO
Primary
Human