CD194 (CCR4) Mouse anti-Human, PE, Clone: D8SEE, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-1949-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15516936

Quantity Price
1 £ 170.59 / 100 tests
EU Stock 4
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Description and Specification

Specification

Format Conjugated
Species Reactivity Human
Concentration 5μL (0.25μg)/test
Applications Flow Cytometry
Conjugate PE
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Antigen CD194 (CCR4)
Regulatory Status RUO
Gene Alias C-C Motif Chemokine Receptor 4
Quantity 100 tests
Isotype IgG1
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Clone D8SEE
Host Species Mouse

This D8SEE monoclonal antibody reacts with human CD194 (CCR4). CD194, also known as C-C Chemokine Receptor 4 (CCR4) is a member of the G protein-coupled receptor family, a large family characterized by seven transmembrane alpha helical domains. The ligands for CCR4 are CCL17 (TARC) and CCL22 (MDC), which direct the migration of target cells. CCR4 and its ligands, along with the other receptors CCR10 and CLA, are particularly important for the recruitment of T cells into the skin, where they may also play a role in adhesion and extravasation. Although CCR4 expression was originally believed to be restricted to Th2 cells, it has since been observed in some subsets of Th17, Treg, and Th1 cells. It is not expressed by naïve T cells, indicating a role in memory or effector function. Other cells that express CCR4 are activated NK cells, platelets, monocytes, and basophils.