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CD194 (CCR4), PE, clone: D8SEE, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-1949-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15506936

  • £81.11 / 25 tests


Estimated Shipment date
from Supplier 02-07-2018
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Description

Description

Description: This D8SEE monoclonal antibody reacts with human CD194 (CCR4). CD194, also known as C-C Chemokine Receptor 4 (CCR4) is a member of the G protein-coupled receptor family, a large family characterized by seven transmembrane alpha helical domains. The ligands for CCR4 are CCL17 (TARC) and CCL22 (MDC), which direct the migration of target cells. CCR4 and its ligands, along with the other receptors CCR10 and CLA, are particularly important for the recruitment of T cells into the skin, where they may also play a role in adhesion and extravasation. Although CCR4 expression was originally believed to be restricted to Th2 cells, it has since been observed in some subsets of Th17, Treg, and Th1 cells. It is not expressed by naive T cells, indicating a role in memory or effector function. Other cells that express CCR4 are activated NK cells, platelets, monocytes, and basophils.Applications Reported: This D8SEE antibody has been reported for use in flow cytometric analysis.Applications Tested: This D8SEE antibody has been pre-titrated and tested by flow cytometric anaylis of normal human peripheral blood cells. This can be used at 5 μL (0.25 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

CD194 (CCR4)
Monoclonal
5μl/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P51679
CC-CKR-4, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5, MGC88293
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
D8SEE
PE
CCR4
Conjugated
CCR4
IgG1, kappa
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary
1233
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