CD193 (CCR3) Mouse anti-Human, PE, Clone: eBio5E8-G9-B4 (5E8-G9-B4), eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-1939-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15586926

Quantity Price
1 £ 48.31 / 25 tests
Estimated Shipment date
from Supplier 09-05-2017
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Description and Specification

Specification

Host Species Murine
Quantity 25 Tests
Concentration 5μL (0.06μg)/test
Regulatory Status RUO
Clone eBio5E8-G9-B4 (5E8-G9-B4)
Conjugate PE
Isotype IgG2b
Applications Flow Cytometry
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias CKR3
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Species Reactivity Human
Format Conjugated
Antigen CD193 (CCR3)

The eBio5E8-G9-B4 monoclonal antibody reacts with human CD193 (CCR3, CKR3). CD193 is a member of the seven transmembrane G-protein coupled receptor (GPCR) family, and is a high affinity chemokine receptor for the chemokines eotaxin-1 (CCL11), eotaxin-2 (CCL24), eotaxin-3 (CCL26) and MCP-4 (CCL13), but has also been reported to bind RANTES, MCP-3 and MCP-4. CD193 is highly expressed on the surface of eosinophils, and is the key eosinophil chemokine receptor responsible for the regulation of eosinophil migration and function. In addition to eosinophils, CD193 is also expressed on CD4+ TH2 cells, basophils, mast cells, mononuclear phagocytes, platelets, CD34+ hematopoietic progenitors and airway epithelial cells. CD193 likely plays an important role in the migration of eosinophils in allergic airway inflammation and asthma. CD193 can also serve as a receptor for HIV-1 cell entry.