CD185 (CXCR5) Mouse anti-Human, PE-eFluor 610, Clone: MU5UBEE, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 61-9185-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15540577

Quantity Price
1 £ 84.99 / 25 tests
Estimated Shipment date
from Supplier 04-04-2017
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Description and Specification

Specification

Isotype IgG2b
Concentration 5μL (0.125μg)/test
Species Reactivity Human, Non-human primate, Rhesus Ma
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Conjugate PE-eFluor 610
Antigen CD185 (CXCR5)
Gene Alias C-X-C chemokine receptor type 5, BLR1, MDR15
Applications Flow Cytometry
Quantity 25 tests
Primary or Secondary Primary
Host Species Mouse
Format Conjugated
Clone MU5UBEE
Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal

The MU5UBEE monoclonal antibody reacts with human and non-human primate CD185. CD185, which is also known as C-X-C chemokine receptor 5 (CXCR5) and Burkitt lymphoma receptor 1 (BLR1), is a seven transmembrane G protein-coupled receptor originally identified in Burkitt’s lymphoma. In peripheral blood, CD185 is expressed on B cells, CD4+ T cells (but not Th1 or Th2 cells), as well as on a subpopulation of memory (CD45RO+) T cells. Circulating CD185+ T cells are in a resting state and migrate to the lymph nodes due to expression of CCR7 and CD62L. In tonsil, CD185 is expressed on nearly all CD4+ cells together with CD45RO and activation markers such as CD69 and ICOS. Tonsillar CD185+ cells have been shown to induce antibody production when co-cultured with B cells, thus supporting their role in providing help to B cells. Furthermore, this chemokine receptor plays a critical role in lymphocyte trafficking, in particular T cell migration into the B cell follicles of germinal centers in response to CXCL13, making CD185 an established marker of follicular helper T cells.

The MU5UBEE monoclonal antibody also crossreacts with Rhesus macaque.