CD185 (CXCR5) Mouse anti-Human, PE, Clone: MU5UBEE, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-9185-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15577186

Quantity Price
1 £ 205.24 / 100 tests
EU Stock 18
Add to basket


Description and Specification

Specification

Applications Flow Cytometry
Format Conjugated
Regulatory Status RUO
Quantity 100 tests
Monoclonal or Polyclonal Monoclonal
Isotype IgG2b
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Conjugate PE
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Clone MU5UBEE
Species Reactivity Human, Non-human primate, Rhesus Ma
Concentration 5μL (0.125μg)/test
Gene Alias C-X-C chemokine receptor type 5, BLR1, MDR15
Antigen CD185 (CXCR5)
Host Species Mouse

The MU5UBEE monoclonal antibody reacts with human and non-human primate CD185. CD185, which is also known as C-X-C chemokine receptor 5 (CXCR5) and Burkitt lymphoma receptor 1 (BLR1), is a seven transmembrane G protein-coupled receptor originally identified in Burkitt’s lymphoma. In peripheral blood, CD185 is expressed on B cells, CD4+ T cells (but not Th1 or Th2 cells), as well as on a subpopulation of memory (CD45RO+) T cells. Circulating CD185+ T cells are in a resting state and migrate to the lymph nodes due to expression of CCR7 and CD62L. In tonsil, CD185 is expressed on nearly all CD4+ cells together with CD45RO and activation markers such as CD69 and ICOS. Tonsillar CD185+ cells have been shown to induce antibody production when co-cultured with B cells, thus supporting their role in providing help to B cells. Furthermore, this chemokine receptor plays a critical role in lymphocyte trafficking, in particular T cell migration into the B cell follicles of germinal centers in response to CXCL13, making CD185 an established marker of follicular helper T cells.

The MU5UBEE monoclonal antibody also crossreacts with Rhesus macaque.