CD185 (CXCR5) Mouse anti-Human, Clone: MU5UBEE, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9185-80

25UG Anti-Human CD185 (CXCR5) Purified

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15507596

Quantity Price
1 £ 92.2 / 25µg
Estimated Shipment date
from Supplier 24-02-2017
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Description and Specification

Specification

Format Purified
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Applications Flow Cytometry
Isotype IgG2b
Quantity 25μg
Species Reactivity Human, Non-human primate, Rhesus Ma
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Concentration 0.5mg/mL
Antigen CD185 (CXCR5)
Host Species Mouse
Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Clone MU5UBEE
Conjugate Unlabeled

The MU5UBEE monoclonal antibody reacts with Mouse CD185. CD185, which is also known as C-X-C chemokine receptor 5 (CXCR5) and Burkitt lymphoma receptor 1 (BLR1), is a seven transmembrane G protein-coupled receptor originally identified in Burkitt’s lymphoma. In peripheral blood, CXCR5 is expressed on B cells, CD4+ T cells (but not Th1 or Th2 cells), as well as on a subpopulation of memory (CD45RO+) T cells. CXCR5+ circulating T cells are in a resting state and migrate to the lymph nodes due to expression of CCR7 and CD62L. In tonsil, CXCR5 is expressed on nearly all CD4+ cells along with CD45RO and such activation markers as CD69 and ICOS. Tonsillar CXCR5+ cells have been shown to induce antibody production when co-cultured with B cells, thus supporting their role in providing B cell help. Furthermore, this chemokine receptor plays a critical role in lymphocyte trafficking, in particular T cell migration into the B cell follicles of germinal centers in response to CXCL13, making CXCR5 an established marker of follicular helper T cells.