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CD185 (CXCR5), Biotin, clone: MU5UBEE, eBioscience™

Mouse Monoclonal Antibody

Marque:  Affymetrix eBioscience 13-9185-80

Code : NEW

Informations supplémentaires : Weight : 0.09500kg

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Code produit. 15547356

  • £61.93 / 25µg


EU Stock 3
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For Research Use Only.


Description

Description

Description: The MU5UBEE monoclonal antibody reacts with human and non-human primate CD185. CD185, which is also known as C-X-C chemokine receptor 5 (CXCR5) and Burkitt lymphoma receptor 1 (BLR1), is a seven transmembrane G protein-coupled receptor originally identified in Burkitt's lymphoma. In peripheral blood, CD185 is expressed on B cells, CD4+ T cells (but not Th1 or Th2 cells), as well as on a subpopulation of memory (CD45RO+) T cells. Circulating CD185+ T cells are in a resting state and migrate to the lymph nodes due to expression of CCR7 and CD62L. In tonsil, CD185 is expressed on nearly all CD4+ cells together with CD45RO and activation markers such as CD69 and ICOS. Tonsillar CD185+ cells have been shown to induce antibody production when co-cultured with B cells, thus supporting their role in providing help to B cells. Furthermore, this chemokine receptor plays a critical role in lymphocyte trafficking, in particular T cell migration into the B cell follicles of germinal centers in response to CXCL13, making CD185 an established marker of follicular helper T cells.The MU5UBEE monoclonal antibody also crossreacts with Rhesus macaque.Applications Reported: This MU5UBEE antibody has been reported for use in flow cytometric analysis.Applications Tested: This MU5UBEE antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5μL (0.125μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Filtration: 0.2μm post-manufacturing filtered.
Spécification

Spécification

CD185 (CXCR5)
MU5UBEE
Biotin
Conjugated
Murine
25μg
Store at 2-8°C. Do not freeze.
Monoclonal
Flow Cytometry
5μL (0.125μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
C-X-C chemokine receptor type 5, BLR1, MDR15
IgG2b
RUO
Primary
Rhesus
Vidéos