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CD185 (CXCR5), Biotin, clone: MU5UBEE, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-9185-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15557356

  • £156.21 / 100µg


EU Stock 1
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Description

Description

Description: The MU5UBEE monoclonal antibody reacts with human and non-human primate CD185. CD185, which is also known as C-X-C chemokine receptor 5 (CXCR5) and Burkitt lymphoma receptor 1 (BLR1), is a seven transmembrane G protein-coupled receptor originally identified in Burkitt's lymphoma. In peripheral blood, CD185 is expressed on B cells, CD4+ T cells (but not Th1 or Th2 cells), as well as on a subpopulation of memory (CD45RO+) T cells. Circulating CD185+ T cells are in a resting state and migrate to the lymph nodes due to expression of CCR7 and CD62L. In tonsil, CD185 is expressed on nearly all CD4+ cells together with CD45RO and activation markers such as CD69 and ICOS. Tonsillar CD185+ cells have been shown to induce antibody production when co-cultured with B cells, thus supporting their role in providing help to B cells. Furthermore, this chemokine receptor plays a critical role in lymphocyte trafficking, in particular T cell migration into the B cell follicles of germinal centers in response to CXCL13, making CD185 an established marker of follicular helper T cells.The MU5UBEE monoclonal antibody also crossreacts with Rhesus macaque.Applications Reported: This MU5UBEE antibody has been reported for use in flow cytometric analysis.Applications Tested: This MU5UBEE antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5μL (0.125μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

CD185 (CXCR5)
Monoclonal
0.5mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P32302
CXC Chemokine Receptor 5, Fusin, LESTR, HUMSTR
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Rhesus
Flow Cytometry
MU5UBEE
Biotin
CXCR5
Conjugated
CXCR5
IgG2b, kappa
100μg
Store at 2-8°C. Do not freeze.
Primary
643
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