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CD184 (CXCR4), PE, clone: 2B11, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-9991-81

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15299379

  • £95.25 / 50µg


EU Stock 6
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Description

Description

Description: The 2B11 monoclonal antibody reacts with mouse and human CXCR4, also known as CD184, Fusin, LESTR, or HUMSTR. Fusin is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. In addition it has been shown to play a role in lymphocyte migration. The ligand for CXCR4 is SDF1. CXCR4 is required for maintenance of granulocyte progenitors in the bone marrow and essential for B cell development. Expression of CXCR4 is different between mice and human. In the thymus CXCR4 is restricted to CD4+CD8+ cells while in the spleen predominant expression is found on B lymphocytes.The monoclonal antibody 2B11 recognizes the amino terminus of CXCR4 and has been reported to have functional activity; it does not block SDF1a but causes internalization of the receptor.Applications Reported: This 2B11 antibody has been reported for use in flow cytometric analysis.Applications Tested: This 2B11 antibody has been tested by flow cytometric analysis of mouse thymocytes. This can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.It is recommended that the incubation time with 2B11 antibody by at least 45 minutes for optimal staining.Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

CD184 (CXCR4)
Monoclonal
0.2mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P70658
CXC Chemokine Receptor 4, Fusin, LESTR, HUMSTR
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Murine
Flow Cytometry
2B11
PE
Cxcr4
Conjugated
Cxcr4
IgG2b, kappa
50μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary
12767
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