CD184 (CXCR4) Rat anti-Mouse, eFluor 450, Clone: 2B11, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 48-9991-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15569856

Quantity Price
1 £ 80.62 / 25µg
EU Stock 3
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Description and Specification

Specification

Isotype IgG2b
Gene Alias Fusin, C-X-C chemokine receptor type 4, SDF-1 Receptor
Clone 2B11
Concentration 0.2mg/mL
Applications Flow Cytometry
Monoclonal or Polyclonal Monoclonal
Antigen CD184 (CXCR4)
Conjugate eFluor 450
Host Species Rat
Quantity 25μg
Species Reactivity Mouse
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Regulatory Status RUO
Primary or Secondary Primary
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

The 2B11 monoclonal antibody reacts with mouse and human CXCR4, also known as CD184, Fusin, LESTR, or HUMSTR. Fusin is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. In addition it has been shown to play a role in lymphocyte migration. The ligand for CXCR4 is SDF1. CXCR4 is required for maintenance of granulocyte progenitors in the bone marrow and essential for B cell development. Expression of CXCR4 is different between mice and human. In the thymus CXCR4 is restricted to CD4+CD8+ cells while in the spleen predominant expression is found on B lymphocytes.

The monoclonal antibody 2B11 recognizes the amino terminus of CXCR4 and has been reported to have functional activity; it does not block SDF1a but causes internalization of the receptor.