CD184 (CXCR4) Rat anti-Mouse, Biotin, Clone: 2B11, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-9991-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15380150

Quantity Price
1 £ 133.91 / 100µg
EU Stock 4
Add to basket


Description and Specification

Specification

Antigen CD184 (CXCR4)
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Applications Flow Cytometry
Storage Requirements Store at 2-8°C. Do not freeze.
Monoclonal or Polyclonal Monoclonal
Concentration 0.5mg/mL
Gene Alias Fusin
Conjugate Biotin
Clone 2B11
Host Species Rat
Primary or Secondary Primary
Isotype IgG2b
Format Conjugated
Regulatory Status RUO
Species Reactivity Mouse
Quantity 100μg

The 2B11 monoclonal antibody reacts with mouse and human CXCR4, also known as CD184, Fusin, LESTR, or HUMSTR. Fusin is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. In addition it has been shown to play a role in lymphocyte migration. The ligand for CXCR4 is SDF1. CXCR4 is required for maintenance of granulocyte progenitors in the bone marrow and essential for B cell development. Expression of CXCR4 is different between mice and human. In the thymus CXCR4 is restricted to CD4+CD8+ cells while in the spleen predominant expression is found on B lymphocytes.

The monoclonal antibody 2B11 recognizes the amino terminus of CXCR4 and has been reported to have functional activity; it does not block SDF1a but causes internalization of the receptor.