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CD184 (CXCR4) Monoclonal Antibody (12G5), PE-Cyanine7, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

£257.00

Specifications

Antigen CD184 (CXCR4)
Clone 12G5
Concentration 5 μL/Test
Applications Flow Cytometry
Classification Monoclonal
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Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15518716
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Affymetrix eBioscience
25-9999-42
100 Tests
£257.00
100 tests
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Description

Description

Description: The 12G5 monoclonal antibody reacts with human CD184 (CXCR4), also termed Fusin, LESTR, or HUMSTR. CD184 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. CD184 is expressed predomitly on naive T cell subsets of peripheral blood and is rapidly upregulated by PHA and IL-2 stimulation. The 12G5 antibody shows partial inhibition of chemotaxis and calcium influx induced by SDF-1 (the natural ligand of CD184), blocks CD4-independent HIV-2 infection, and blocks CD4-dependent infection by some T-tropic HIV-1 isolates. Applications Reported: This 12G5 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 12G5 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.25 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Light sensitivity: This tandem dye is sensitive photo-induced oxidation. Please protect this vial and stained samples from light. Fixation: Samples can be stored in IC Fixation Buffer (cat. 00-8222) (100 μL cell sample + 100 μL IC Fixation Buffer) or 1-step Fix/Lyse Solution (cat.

CD184 (CXCR4) Monoclonal antibody specifically detects CD184 (CXCR4) in Human samples. It is validated for Flow Cytometry.
Specifications

Specifications

CD184 (CXCR4)
5 μL/Test
Monoclonal
Liquid
RUO
P61073
IgG2a κ
Affinity chromatography
Antibody
12G5
Flow Cytometry
PE-Cyanine7
Mouse
Human
7852
Primary
4° C, store in dark, DO NOT FREEZE!
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