CD184 (CXCR4) Mouse anti-Human, PE-Cy5, Clone: 12G5, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 15-9999-42

100TEST Anti-Human CD184 (CXCR4) PE-Cyanine5

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15597766

Quantity Price
1 £ 176.7 / 100 tests
Estimated Shipment date
from Supplier 27-03-2017
Add to basket


Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Host Species Mouse
Applications Flow Cytometry
Isotype IgG2a
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Clone 12G5
Concentration 5μL (0.5μg)/test
Conjugate PE-Cy5
Antigen CD184 (CXCR4)
Format Conjugated
Gene Alias Fusin
Quantity 100 tests
Regulatory Status RUO
Species Reactivity Human

The 12G5 monoclonal antibody reacts with human CD184 (CXCR4), also termed Fusin, LESTR, or HUMSTR. CD184 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. CD184 is expressed predominantly on naïve T cell subsets of peripheral blood and is rapidly upregulated by PHA and IL-2 stimulation. The 12G5 antibody shows partial inhibition of chemotaxis and calcium influx induced by SDF-1 (the natural ligand of CD184), blocks CD4-independent HIV-2 infection, and blocks CD4-dependent infection by some T-tropic HIV-1 isolates.