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CD184 (CXCR4), PE, clone: 12G5, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-9999-41

Code : NEW

Additional Details : Weight : 0.00025kg

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Product Code. 15246467

  • £74.43 / Each


EU Stock 4
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Description

Description

Description: The 12G5 monoclonal antibody reacts with human CD184 (CXCR4), also termed Fusin, LESTR, or HUMSTR. CD184 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. CD184 is expressed predominantly on naive T cell subsets of peripheral blood and is rapidly upregulated by PHA and IL-2 stimulation. The 12G5 antibody shows partial inhibition of chemotaxis and calcium influx induced by SDF-1 (the natural ligand of CD184), blocks CD4-independent HIV-2 infection, and blocks CD4-dependent infection by some T-tropic HIV-1 isolates.Applications Reported: This 12G5 antibody has been reported for use in flow cytometric analysis.Applications Tested: The 12G5 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.25 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

CD184
Monoclonal
5μl/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P61073
CXC Chemokine Receptor 4, Fusin, LESTR, HUMSTR
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
12G5
PE
CXCR4
Conjugated
CXCR4
IgG2a, kappa
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary
7852
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