CD184 (CXCR4) Mouse anti-Human, PE, Clone: 12G5, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-9999-41

UNSPSC: 12352200

Code: NEW

Additional Details:
Additional Details: Weight: 0.00025kg



Disclaimers: For Research Use Only.

Product Code. 15246467

Quantity Price
1 £ 72.77 / Each
EU Stock 3
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Description and Specification

Specification

Species Reactivity Human
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.25μg)/test
Isotype IgG2a
Monoclonal or Polyclonal Monoclonal
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Antigen CD184 (CXCR4)
Applications Flow Cytometry
Host Species Mouse
Primary or Secondary Primary
Regulatory Status RUO
Conjugate PE
Gene Alias Fusin
Quantity 25 tests
Clone 12G5
Format Conjugated

The 12G5 monoclonal antibody reacts with human CD184 (CXCR4), also termed Fusin, LESTR, or HUMSTR. CD184 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. CD184 is expressed predominantly on naïve T cell subsets of peripheral blood and is rapidly upregulated by PHA and IL-2 stimulation. The 12G5 antibody shows partial inhibition of chemotaxis and calcium influx induced by SDF-1 (the natural ligand of CD184), blocks CD4-independent HIV-2 infection, and blocks CD4-dependent infection by some T-tropic HIV-1 isolates.