CD184 (CXCR4) Mouse anti-Human, Clone: 12G5, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-9999-85

500UG:ANTI-HUMAN CD184(CXCR4)FUNCTIONAL GRADE

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15288857

Quantity Price
1 £ 257.0 / 500µg
Estimated Shipment date
from Supplier 24-02-2017
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Description and Specification

Specification

Formulation aqueous buffer, no sodium azide
Gene Alias Fusin
Applications Flow Cytometry
Applications Functional Assay
Regulatory Status RUO
Species Reactivity Human
Primary or Secondary Primary
Antigen CD184 (CXCR4)
Format Purified
Host Species Mouse
Isotype IgG2a
Quantity 500μg
Storage Requirements Store at 2-8°C.
Monoclonal or Polyclonal Monoclonal
Clone 12G5
Concentration 1mg/mL
Conjugate Unlabeled

The 12G5 monoclonal antibody reacts with human CD184 (CXCR4), also termed Fusin, LESTR, or HUMSTR. CD184 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. CD184 is expressed predominantly on naïve T cell subsets of peripheral blood and is rapidly upregulated by PHA and IL-2 stimulation. The 12G5 antibody shows partial inhibition of chemotaxis and calcium influx induced by SDF-1 (the natural ligand of CD184), blocks CD4-independent HIV-2 infection, and blocks CD4-dependent infection by some T-tropic HIV-1 isolates.