CD184 (CXCR4) Mouse anti-Human, Clone: 12G5, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-9999-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15288857

Quantity Price
1 £ 225.61 / 500µg
Estimated Shipment date
from Supplier 04-04-2017
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Description and Specification

Specification

Species Reactivity Human
Regulatory Status RUO
Gene Alias Fusin
Applications Flow Cytometry
Applications Functional Assay
Formulation aqueous buffer, no sodium azide
Primary or Secondary Primary
Storage Requirements Store at 2-8°C.
Host Species Mouse
Isotype IgG2a
Conjugate Unlabeled
Antigen CD184 (CXCR4)
Concentration 1mg/mL
Format Purified
Clone 12G5
Quantity 500μg
Monoclonal or Polyclonal Monoclonal

The 12G5 monoclonal antibody reacts with human CD184 (CXCR4), also termed Fusin, LESTR, or HUMSTR. CD184 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. CD184 is expressed predominantly on naïve T cell subsets of peripheral blood and is rapidly upregulated by PHA and IL-2 stimulation. The 12G5 antibody shows partial inhibition of chemotaxis and calcium influx induced by SDF-1 (the natural ligand of CD184), blocks CD4-independent HIV-2 infection, and blocks CD4-dependent infection by some T-tropic HIV-1 isolates.