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CD184 (CXCR4) Mouse anti-Human, Clone: 12G5, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Brand:  Affymetrix eBioscience 16-9999-85

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15288857

  • £225.61 / 500µg


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For Research Use Only.


Description

Description

The 12G5 monoclonal antibody reacts with human CD184 (CXCR4), also termed Fusin, LESTR, or HUMSTR. CD184 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. CD184 is expressed predominantly on naïve T cell subsets of peripheral blood and is rapidly upregulated by PHA and IL-2 stimulation. The 12G5 antibody shows partial inhibition of chemotaxis and calcium influx induced by SDF-1 (the natural ligand of CD184), blocks CD4-independent HIV-2 infection, and blocks CD4-dependent infection by some T-tropic HIV-1 isolates.
Specifications

Specifications

CD184 (CXCR4)
12G5
Unlabeled
Purified
Murine
500μg
Store at 2-8°C.
Monoclonal
Functional Assay
1mg/mL
aqueous buffer, no sodium azide
Fusin
IgG2a
RUO
Primary
Human