CD184 (CXCR4) Mouse anti-Human, Clone: 12G5, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-9999-81

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15278857

Quantity Price
1 £ 91.11 / 50µg
EU Stock 1
Add to basket


Description and Specification

Specification

Gene Alias Fusin
Concentration 1mg/mL
Conjugate Unlabeled
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Isotype IgG2a
Quantity 50μg
Regulatory Status RUO
Antigen CD184 (CXCR4)
Applications Flow Cytometry
Applications Functional Assay
Formulation aqueous buffer, no sodium azide
Host Species Mouse
Species Reactivity Human
Storage Requirements Store at 2-8°C.
Format Purified
Clone 12G5

The 12G5 monoclonal antibody reacts with human CD184 (CXCR4), also termed Fusin, LESTR, or HUMSTR. CD184 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. CD184 is expressed predominantly on naïve T cell subsets of peripheral blood and is rapidly upregulated by PHA and IL-2 stimulation. The 12G5 antibody shows partial inhibition of chemotaxis and calcium influx induced by SDF-1 (the natural ligand of CD184), blocks CD4-independent HIV-2 infection, and blocks CD4-dependent infection by some T-tropic HIV-1 isolates.