CD183 (CXCR3) Armenian Hamster anti-Mouse, PE-Cy7, Clone: CXCR3-173, eBioscience™

Armenian Hamster Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 25-1831-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15528506

Quantity Price
1 £ 86.73 / 25µg
Estimated Shipment date
from Supplier 09-05-2017
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Description and Specification

Specification

Monoclonal or Polyclonal Monoclonal
Host Species Armenian Hamster
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Quantity 25μg
Applications Flow Cytometry
Regulatory Status RUO
Clone CXCR3-173
Antigen CD183 (CXCR3)
Species Reactivity Mouse
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Primary or Secondary Primary
Gene Alias C-X-C chemokine receptor type 3, IP-10 receptor
Concentration 0.2mg/mL
Conjugate PE-Cy7
Format Conjugated
Isotype IgG

The monoclonal antibody CXCR3-173 recognizes mouse CD183 also known as CXCR3. CD183 is a seven transmembrane G-protein liked chemokine receptor which binds three ligands; CXCL9 (mig), CXCL10 (IP-10)and CXCL11 (ITAC). CD183 as been shown to play a role in CD4 T cell responses to grafts. CXCR3 knockout mice have compromised allograft rejection responses. Expression is found on NK cells, a subset of T lymphocytes and a subset of Tregs as well as preferential expression on Th1-polarized cells.

The antibody CXCR3-173 has been shown to affect chemotaxis in response to ligand. The presence of ligand eliminates staining with the antibody. In vivo addition of the antibody delays cardiac and pancreatic islet allograft rejection.