CD183 (CXCR3) Armenian Hamster anti-Mouse, APC, Clone: CXCR3-173, eBioscience™

Armenian Hamster Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-1831-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15310700

Quantity Price
1 £ 186.31 / 100µg
EU Stock 2
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Description and Specification

Specification

Species Reactivity Mouse
Concentration 0.2mg/mL
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Applications Flow Cytometry
Conjugate APC
Gene Alias C-X-C chemokine receptor type 3, IP-10 receptor
Primary or Secondary Primary
Isotype IgG
Host Species Armenian Hamster
Antigen CD183 (CXCR3)
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Quantity 100μg
Clone CXCR3-173
Monoclonal or Polyclonal Monoclonal
Regulatory Status RUO
Format Conjugated

The monoclonal antibody CXCR3-173 recognizes mouse CD183 also known as CXCR3. CD183 is a seven transmembrane G-protein liked chemokine receptor which binds three ligands; CXCL9 (mig), CXCL10 (IP-10)and CXCL11 (ITAC). CD183 as been shown to play a role in CD4 T cell responses to grafts. CXCR3 knockout mice have compromised allograft rejection responses. Expression is found on NK cells, a subset of T lymphocytes and a subset of Tregs as well as preferential expression on Th1-polarized cells.

The antibody CXCR3-173 has been shown to affect chemotaxis in response to ligand. The presence of ligand eliminates staining with the antibody. In vivo addition of the antibody delays cardiac and pancreatic islet allograft rejection.