CD182 (CXCR2) Mouse anti-Human, PerCP-eFluor 710, Clone: ebio5E8-C7-F10 (5E8-C7-F10), eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 46-1829-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15569206

Quantity Price
1 £ 75.3 / 25 tests
Estimated Shipment date
from Supplier 05-05-2017
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Description and Specification

Specification

Isotype IgG1
Antigen CD182 (CXCR2)
Applications Flow Cytometry
Primary or Secondary Primary
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Quantity 25 tests
Gene Alias C-X-C chemokine receptor type 2, Interleukin-8 Receptor B
Format Conjugated
Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Concentration 5μL (0.25μg)/test
Conjugate PerCP-eFluor 710
Clone ebio5E8-C7-F10 (5E8-C7-F10)
Species Reactivity Human
Host Species Mouse

The eBio5E8-C7-F10 monoclonal antibody reacts with human CD182 (CXCR2, IL-8R beta). CD182 is a 67-70kDa member of the seven-transmembrane spanning G-protein coupled receptor (GPCR) family. CD182 is expressed as a homodimer, or a heterodimer with CD181 (CXCR1, IL-8R alpha) and is expressed on granulocytes, NK cells, a subset of T cells, mast cells, monocytes, endothelial cells, megakaryocytes and oligodendrocytes. Binding of it's ligands, which include IL-8, NAP-2, GCP-2 and GRO alpha, -beta and -gamma, induces several biological outcomes such as cell activation, chemotaxis, proliferation and angiogenesis. There are several functional differences between CD181 and CD182. Both receptors are able to mediate chemotaxis and intracellular calcium changes, but only CD181 mediates phospolipase D activation and respiratory burst. Furthermore, studies have shown that IL-8 predominantly mediates its effects on neutrophil function through CD181.