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CD182 (CXCR2) Mouse anti-Human, Clone: eBio5E8-C7-F10 (5E8-C7-F10), eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-1829-85

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15277277

  • £158.36 / 500µg


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For Research Use Only.


Description

Description

The eBio5E8-C7-F10 monoclonal antibody reacts with human CD182 (CXCR2, IL-8Rβ). CD182 is a 67-70kDa member of the seven-transmembrane spanning G-protein coupled receptor (GPCR) family. CD182 is expressed as a homodimer, or a heterodimer with CD181 (CXCR1, IL-8Rα) and is expressed on granulocytes, NK cells, a subset of T cells, mast cells, monocytes, endothelial cells, megakaryocytes and oligodendrocytes. Binding of it's ligands, which include IL-8, NAP-2, GCP-2 and GRO-α, -β and -γ, induces several biological outcomes such as cell activation, chemotaxis, proliferation and angiogenesis. There are several functional differences between CD181 and CD182. Both receptors are able to mediate chemotaxis and intracellular calcium changes, but only CD181 mediates phospolipase D activation and respiratory burst. Furthermore, studies have shown that IL-8 predominantly mediates its effects on neutrophil function through CD181.
Specifications

Specifications

CD182 (CXCR2)
eBio5E8-C7-F10 (5E8-C7-F10)
Unconjugated
Purified
Murine
500μg
Store at 2-8°C.
Monoclonal
Flow Cytometry
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Interleukin-8 Receptor B, IL8RB, IL98Rb
IgG1
RUO
Primary
Human
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