CD182 (CXCR2) Mouse anti-Human, Clone: eBio5E8-C7-F10 (5E8-C7-F10), eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-1829-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15257277

Quantity Price
1 £ 36.08 / 25µg
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Monoclonal or Polyclonal Monoclonal
Antigen CD182 (CXCR2)
Host Species Mouse
Applications Flow Cytometry
Gene Alias Interleukin-8 Receptor B, IL8RB, IL98Rb
Quantity 25μg
Conjugate Unlabeled
Species Reactivity Human
Primary or Secondary Primary
Storage Requirements Store at 2-8°C.
Format Purified
Concentration 0.5mg/mL
Isotype IgG1
Regulatory Status RUO
Clone eBio5E8-C7-F10 (5E8-C7-F10)
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

The eBio5E8-C7-F10 monoclonal antibody reacts with human CD182 (CXCR2, IL-8Rβ). CD182 is a 67-70kDa member of the seven-transmembrane spanning G-protein coupled receptor (GPCR) family. CD182 is expressed as a homodimer, or a heterodimer with CD181 (CXCR1, IL-8Rα) and is expressed on granulocytes, NK cells, a subset of T cells, mast cells, monocytes, endothelial cells, megakaryocytes and oligodendrocytes. Binding of it's ligands, which include IL-8, NAP-2, GCP-2 and GRO-α, -β and -γ, induces several biological outcomes such as cell activation, chemotaxis, proliferation and angiogenesis. There are several functional differences between CD181 and CD182. Both receptors are able to mediate chemotaxis and intracellular calcium changes, but only CD181 mediates phospolipase D activation and respiratory burst. Furthermore, studies have shown that IL-8 predominantly mediates its effects on neutrophil function through CD181.