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CD181 (CXCR1) Mouse anti-Human, Clone: eBio8F1-1-4 (8F1-1-4), eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-1819-82

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15247277

  • £66.65 / 100µg


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Disclaimers:

For Research Use Only.


Description

Description

The eBio8F1-1-4 monoclonal antibody reacts with human CD181 (CXCR1, IL-8Rα). CD181 is a 67-70kDa member of the 7-transmembrane spanning G-protein coupled receptor (GPCR) family. CD181 is expressed as a homodimer, or a heterodimer with CD182 (CXCR2, IL-8Rβ) and is expressed on granulocytes, NK cells, a subset of T cells, mast cells, monocytes, endothelial cells, megakaryocytes and oligodendrocytes. Binding of it's ligands, which include IL-8, NAP-2, GCP-2 and GRO-α, induces several biological outcomes such as cell activation, chemotaxis, proliferation and angiogenesis. There are several functional differences between CD181 and CD182. Both receptors are able to mediate chemotaxis and intracellular calcium changes, but only CD181 mediates phospolipase D activation and respiratory burst. Furthermore, studies have shown that IL-8 predominantly mediates its effects on neutrophil function through CD181.
Specifications

Specifications

CD181 (CXCR1)
eBio8F1-1-4 (8F1-1-4)
Unlabeled
Purified
Murine
100μg
Store at 2-8°C.
Monoclonal
Flow Cytometry
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Interleukin-8 Receptor A, IL-8Ra, IL8RA
IgG2b
RUO
Primary
Human