missing translation for 'onlineSavingsMsg'
Learn More

CD180 (RP105) Mouse anti-Human, PE, Clone: MHR73-11, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-1809-41

Code : NEW

Additional Details : Weight : 0.23750kg

 View more versions of this product

Product Code. 15516926

  • £72.77 / 25 tests


Estimated Shipment date
from Supplier 31-10-2017
Add to basket

Disclaimers:

For Research Use Only.


Description

Description

The MHR73-11 monoclonal antibody reacts with human CD180 (RP105). This 105kDa type I transmembrane molecule is a member of the TLR family of proteins characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. RP105 physically associates with another molecule called MD-1 and is expressed on B, monocytes/macrophages, and dendritic cells. Histological studies show that RP105 is expressed mainly on mature B cells in mantle zones, while germinal center cells are either dull or negative. The RP105/MD-1 complex in concert with TLR4 mediates B cell recognition and signaling of LPS. MHR73-11 activates B cells, leading to increases in cell size, expression of the costimulatory molecule CD80, and DNA synthesis. Moreover, ligation of RP105 protects B cells from irradiation- or dexamethasone-induced apoptosis. Thus, RP105 is a signal transduction molecule and plays a role in regulation of B cell growth and death. A significant proportion of circulating B cells in SLE patients is RP105 negative. Loss of RP105 is associated with B cell activation and increased disease activity in SLE patients.
Specifications

Specifications

CD180 (RP105)
MHR73-11
PE
Conjugated
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.5μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
RP-105, Toll-like Receptor, TLR Family
IgG1
RUO
Primary
Human