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CD180 (RP105) Mouse anti-Human, Clone: MHR73-11, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-1809-80

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15217277

  • £54.42 / 25µg


Estimated Shipment
30-10-2017
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Disclaimers:

For Research Use Only.


Description

Description

The MHR73-11 monoclonal antibody reacts with human CD180 (RP105). This 105kDa type I transmembrane molecule is a member of the TLR family of proteins characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. RP105 physically associates with another molecule called MD-1 and is expressed on B, monocytes/macrophages, and dendritic cells. Histological studies show that RP105 is expressed mainly on mature B cells in mantle zones, while germinal center cells are either dull or negative. The RP105/MD-1 complex in concert with TLR4 mediates B cell recognition and signaling of LPS. MHR73-11 activates B cells, leading to increases in cell size, expression of the costimulatory molecule CD80, and DNA synthesis. Moreover, ligation of RP105 protects B cells from irradiation- or dexamethasone-induced apoptosis. Thus, RP105 is a signal transduction molecule and plays a role in regulation of B cell growth and death. A significant proportion of circulating B cells in SLE patients is RP105 negative. Loss of RP105 is associated with B cell activation and increased disease activity in SLE patients.
Specifications

Specifications

CD180 (RP105)
MHR73-11
Unconjugated
Purified
Murine
25μg
Store at 2-8°C.
Monoclonal
Immunoprecipitation
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
RP-105, Toll-like Receptor, TLR Family
IgG1
RUO
Primary
Human