CD178 (CD95 Ligand) Mouse anti-Human, Clone: NOK-1, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-9919-85

500UG:ANTI-HUMAN CD178(CD95 LIGAND)FUNCTIONAL

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15258837

Quantity Price
1 £ 232.0 / 500µg
Estimated Shipment date
from Supplier 12-12-2016
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Description and Specification

Specification

Antigen CD178 (CD95 Ligand)
Applications Flow Cytometry
Applications Functional Assay
Clone NOK-1
Concentration 1mg/mL
Conjugate Unlabeled
Format Purified
Formulation aqueous buffer, no sodium azide
Gene Alias CD95L, Fas ligand, FasL
Host Species Mouse
Isotype IgG1
Quantity 500μg
Regulatory Status RUO
Species Reactivity Human
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

The NOK-1 monoclonal antibody reacts with human Fas (CD95) Ligand, a 40kDa type II transmembrane glycoprotein. FasL is a member of the TNF family and is expressed by neutrophils, monocytes, and activated T cells and NK cells. The interaction of FasL with its receptor (CD95, Fas) induces Fas-mediated killing of lymphocytes. Human FasL is cleaved from the surface by matrix metalloproteinases (MMPs), resulting in a 26kDa soluble form. Therefore for optimal detection of surface FasL on activated peripheral blood cells, incubation of cells with an MMP inhibitor is recommended.