CD172a (SIRP alpha) Rat anti-Mouse, PE, Clone: P84, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-1721-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15278699

Quantity Price
1 £ 84.99 / 25µg
EU Stock 2
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Description and Specification

Specification

Host Species Rat
Concentration 0.2mg/mL
Applications Flow Cytometry
Isotype IgG1
Conjugate PE
Antigen CD172a (SIRP alpha)
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Species Reactivity Mouse
Quantity 25μg
Regulatory Status RUO
Gene Alias SHPS-1, Signal-regulatory protein alpha-1
Clone P84
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary

This P84 monoclonal antibody reacts with mouse CD172a, also known as signal regulatory protein a (SIRPa). This cell surface glycoprotein consists of three Ig-like extracellular domains and two cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The ITIM domains have been demonstrated to recruit and bind the Src homology 2 domain-containing phosphatases SHP-1 and SHP-2. CD172a is expressed on monocytes, macrophages, dendritic cells, but not on T and B lymphocytes. Moreover, neurons and other tissues of the central nervous system have also been shown to express CD172a. The integrin-associated protein CD47 is the extracellular ligand for CD172a. Studies show that CD172a is involved in dendritic cell-mediated T cell activation, neutrophil migration, and phagocytosis.

This monoclonal antibody has been reported to have neutralizing activity.