CD172a (SIRP alpha) Rat anti-Mouse, Clone: P84, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-1721-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15208587

Quantity Price
1 £ 213.39 / 500µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Format Purified
Antigen CD172a (SIRP alpha)
Regulatory Status RUO
Applications Flow Cytometry
Applications Functional Assay
Formulation aqueous buffer, no sodium azide
Primary or Secondary Primary
Clone P84
Concentration 1mg/mL
Host Species Rat
Quantity 500μg
Monoclonal or Polyclonal Monoclonal
Storage Requirements Store at 2-8°C.
Isotype IgG1
Conjugate Unlabeled
Gene Alias SHPS-1, Signal-regulatory protein alpha-1
Species Reactivity Mouse

This P84 monoclonal antibody reacts with mouse CD172a, also known as signal regulatory protein a (SIRPa). This cell surface glycoprotein consists of three Ig-like extracellular domains and two cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The ITIM domains have been demonstrated to recruit and bind the Src homology 2 domain-containing phosphatases SHP-1 and SHP-2. CD172a is expressed on monocytes, macrophages, dendritic cells, but not on T and B lymphocytes. Moreover, neurons and other tissues of the central nervous system have also been shown to express CD172a. The integrin-associated protein CD47 is the extracellular ligand for CD172a. Studies show that CD172a is involved in dendritic cell-mediated T cell activation, neutrophil migration, and phagocytosis.

This monoclonal antibody has been reported to have neutralizing activity.