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CD172a (SIRP alpha) Rat anti-Mouse, Biotin, Clone: P84, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-1721-82

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15219759

  • £121.67 / 100µg


Estimated Shipment date
from Supplier 28-07-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

This P84 monoclonal antibody reacts with mouse CD172a, also known as signal regulatory protein a (SIRPa). This cell surface glycoprotein consists of three Ig-like extracellular domains and two cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The ITIM domains have been demonstrated to recruit and bind the Src homology 2 domain-containing phosphatases SHP-1 and SHP-2. CD172a is expressed on monocytes, macrophages, dendritic cells, but not on T and B lymphocytes. Moreover, neurons and other tissues of the central nervous system have also been shown to express CD172a. The integrin-associated protein CD47 is the extracellular ligand for CD172a. Studies show that CD172a is involved in dendritic cell-mediated T cell activation, neutrophil migration, and phagocytosis.

This monoclonal antibody has been reported to have neutralizing activity.
Description & Specifications

Specifications

CD172a (SIRP alpha)
P84
Biotin
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Rat
100μg
Store at 2-8°C. Do not freeze.
Monoclonal
Flow Cytometry
0.5mg/mL
Conjugated
SHPS-1, Signal-regulatory protein alpha-1
IgG1
RUO
Primary
Murine