CD172a (SIRP alpha) Rat anti-Mouse, APC, Clone: P84, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-1721-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15380690

Quantity Price
1 £ 84.99 / 25µg
EU Stock 2
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Description and Specification

Specification

Conjugate Allophycocyanin
Primary or Secondary Primary
Clone P84
Isotype IgG1
Format Conjugated
Monoclonal or Polyclonal Monoclonal
Quantity 25μg
Antigen CD172a (SIRP alpha)
Regulatory Status RUO
Gene Alias SHPS-1, Signal-regulatory protein alpha-1
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Species Reactivity Mouse
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Host Species Rat
Applications Flow Cytometry
Concentration 0.2mg/mL

This P84 monoclonal antibody reacts with mouse CD172a, also known as signal regulatory protein a (SIRPa). This cell surface glycoprotein consists of three Ig-like extracellular domains and two cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The ITIM domains have been demonstrated to recruit and bind the Src homology 2 domain-containing phosphatases SHP-1 and SHP-2. CD172a is expressed on monocytes, macrophages, dendritic cells, but not on T and B lymphocytes. Moreover, neurons and other tissues of the central nervous system have also been shown to express CD172a. The integrin-associated protein CD47 is the extracellular ligand for CD172a. Studies show that CD172a is involved in dendritic cell-mediated T cell activation, neutrophil migration, and phagocytosis.

This monoclonal antibody has been reported to have neutralizing activity.