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CD172a (SIRP alpha) Mouse anti-Rat, APC, Clone: OX41, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-1720-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15568036

  • £72.77 / 25µg


EU Stock 2
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Disclaimers:

For Research Use Only.


Specifications

Description

The monoclonal antibody OX41 reacts with rat CD172a, which is also known as signal-regulatory protein alpha (SIRPa). SIRP family members are transmembrane glycoproteins with 3 Ig-like extracellular domains and a cytoplasmic tail containing 2 immunocreceptor tyrosine-based inhibition motifs. CD172a is expressed by monocytes, macrophages, granulocytes, dendritic cells, and neurons. SIRPa association with CD47 inhibits phagocytosis of CD47 presenting cells. Studies suggest that SIRPa ligation prevents phagocytosis by inactivating paxillin and cofilin, proteins involved in cytoskeleton remodeling.
Description & Specifications

Specifications

CD172a (SIRP alpha)
OX41
Allophycocyanin
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
25μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
0.2mg/mL
Conjugated
SIRPa, SHPS1
IgG2a
RUO
Primary
Rat