CD172a (SIRP alpha) Mouse anti-Rat, APC, Clone: OX41, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-1720-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15568036

Quantity Price
1 £ 72.77 / 25µg
EU Stock 2
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Description and Specification

Specification

Isotype IgG2a
Primary or Secondary Primary
Host Species Mouse
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Conjugate APC
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clone OX41
Format Conjugated
Concentration 0.2mg/mL
Applications Flow Cytometry
Gene Alias SIRPa, SHPS1
Species Reactivity Rat
Regulatory Status RUO
Quantity 25μg
Antigen CD172a (SIRP alpha)
Monoclonal or Polyclonal Monoclonal

The monoclonal antibody OX41 reacts with rat CD172a, which is also known as signal-regulatory protein alpha (SIRPa). SIRP family members are transmembrane glycoproteins with 3 Ig-like extracellular domains and a cytoplasmic tail containing 2 immunocreceptor tyrosine-based inhibition motifs. CD172a is expressed by monocytes, macrophages, granulocytes, dendritic cells, and neurons. SIRPa association with CD47 inhibits phagocytosis of CD47 presenting cells. Studies suggest that SIRPa ligation prevents phagocytosis by inactivating paxillin and cofilin, proteins involved in cytoskeleton remodeling.