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CD172a (SIRP alpha) Mouse anti-Rat, APC, Clone: OX41, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-1720-80

Code : NEW

Additional Details : Weight : 0.09500kg

 View more versions of this product

Product Code. 15568036

  • £79.25 / 25µg

Estimated Shipment date
from Supplier 26-03-2020

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Description

Description

CD172a, also known as signal-regulatory protein alpha, is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells and haematopoietic stem cells. CD172a acts as a substrate for several activated tyrosine kinases, including EGFR, PDGFR, src and insulin receptor and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways. Ligand binding of CD172a to integrin-associated protein CD47, results in tyrosine kinase phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of CD172a, mediating the recruitment and activation of the tyrosine phosphatases SHP-1 and SHP-2. These then act as regulators of cellular function, through dephosphorylation of specific substrates. Ligation of CD172a with CD47 has been demonstrated in several regulatory processes, including the inhibition of host cell phagocytosis by macrophages and the bi-directional activation of T cells and DCs.
Specifications

Specifications

CD172a (SIRP alpha)
Monoclonal
0.2 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P97710
Sirpa
IgG2a, kappa
25 μg
4° C, store in dark, DO NOT FREEZE!
Primary
25528
Flow Cytometry
OX41
APC
Sirpa
Liquid
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Rat
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