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CD172a (SIRP alpha) Mouse anti-Human, PerCP-eFluor 710, Clone: 15-414, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-1729-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15549206

  • £87.96 / 25 tests


Estimated Shipment date
from Supplier 31-07-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

This 15-414 monoclonal antibody reacts with human CD172a, also known as signal regulatory protein alpha (SIRP alpha). This cell surface glycoprotein consists of three Ig-like extracellular domains and two cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The ITIM domains have been demonstrated to recruit and bind the Src homology 2 domain-containing phosphatases SHP-1 and SHP-2. CD172a is expressed on monocytes, granulocytes, dendritic cells, and CD34+CD38- hematopoietic progenitor cells but not on T and B lymphocytes. Moreover, neurons have also been shown to express CD172. The integrin-associated protein CD47 is the extracellular ligand for CD172a. Studies show that CD172a is involved in dendritic cell-mediated T cell activation, neutrophil migration, and phagocytosis.
Description & Specifications

Specifications

CD172a (SIRP alpha)
15-414
PerCP-eFluor 710
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.125μg)/test
Conjugated
SIRPa, SHPS-1
IgG2a
RUO
Primary
Human