CD169 (Siglec-1) Mouse anti-Human, PE, Clone: 7-239, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-1699-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15506926

Quantity Price
1 £ 182.82 / 100 tests
Estimated Shipment date
from Supplier 03-05-2017
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Description and Specification

Specification

Gene Alias Sialoadhesin
Antigen CD169 (Siglec-1)
Monoclonal or Polyclonal Monoclonal
Conjugate PE
Concentration 5μL (0.5μg)/test
Clone 7-239
Applications Flow Cytometry
Isotype IgG1
Quantity 100 tests
Species Reactivity Human
Primary or Secondary Primary
Regulatory Status RUO
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Format Conjugated
Host Species Mouse
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

This 7-239 monoclonal antibody reacts with human CD169, also known as Siglec-1 and Sialoadhesin. This type I transmembrane protein is a member of the sialic acid binding Ig-like lectin (Siglec) family. Expressed on macrophages and dendritic cells in peripheral blood, lymph nodes, and spleen in humans, CD169 binds glycoproteins and glycolipids containing N-acetylneuraminyl alpha 2-3-galactose. CD169 expression can also be induced on CD14+ monocytes by interferon-alpha and interferon-gamma to mediate HIV-1 infection. Finally, CD169 has also been shown to be involved in antigen presentation to invariant NK T cells.

This monoclonal antibody has been reported to inhibit erythrocyte binding to CD169-expressing cells.