CD166 (ALCAM) Mouse anti-Human, PE, Clone: 3A6, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-1668-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15586916

Quantity Price
1 £ 164.47 / 100 tests
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Isotype IgG1
Antigen CD166 (ALCAM)
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Applications Flow Cytometry
Species Reactivity Human
Monoclonal or Polyclonal Monoclonal
Gene Alias Activated leukocyte cell adhesion molecule
Regulatory Status RUO
Format Conjugated
Quantity 100 tests
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Concentration 5μL (0.06μg)/test
Clone 3A6
Primary or Secondary Primary
Conjugate PE
Host Species Mouse

This 3A6 monoclonal antibody reacts with human CD166, which is also known as activated leukocyte cell adhesion molecule (ALCAM). CD166 is an immunoglobulin superfamily cell adhesion molecule that is broadly expressed on developing and adult hematopoietic (e.g., activated T and B cells, monocytes, and dendritic cells) and non-hematopoietic (e.g., neural, endothelial, and epithelial) tissues. CD166 has also been detected in melanoma, colorectal carcinoma, as well as cancers of the breast, prostate, and bladder. CD166 mediates cell-cell adhesion by forming low-affinity homophilic interactions (ALCAM-ALCAM) or high-affinity heterophilic interactions with its ligand CD6 (ALCAM-CD6). CD166 plays a role in development, inflammation, and neutrophil migration. Moreover, its expression can be used as a prognostic marker for several cancers and has been reported to be a cancer stem cell marker.

The 3A6 antibody has been reported to induce the internalization of CD166 and its recycling back to the cell surface.