CD163 Mouse anti-Human, PerCP-eFluor 710, Clone: eBioGHI/61 (GHI/61), eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 46-1639-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15589196

Quantity Price
1 £ 78.88 / 25 tests
Estimated Shipment date
from Supplier 03-05-2017
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Description and Specification

Specification

Format Conjugated
Primary or Secondary Primary
Isotype IgG1
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias M130, Hemoglobin Scavenger Receptor, Macrophage marker
Concentration 5μL (0.5μg)/test
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Clone eBioGHI/61 (GHI/61)
Monoclonal or Polyclonal Monoclonal
Quantity 25 tests
Applications Flow Cytometry
Conjugate PerCP-eFluor 710
Species Reactivity Human
Antigen CD163
Regulatory Status RUO
Host Species Mouse

The eBioGHI/61 monoclonal antibody reacts with human CD163 (Haemoglobin Scavenger Receptor, M130), a member of the macrophage scavenger receptor family. CD163 is expressed by tissue macrophages, circulating blood monocytes, and some reports suggest that it may also be expressed by haematopoietic progenitor cells. CD163 functions as a high affinity scavenger receptor for the complex of haemoglobin and haptoglobin which forms to clear haemoglobin from the blood. The high affinity for CD163 is specific for the haemoglobin-haptoglobin complex, whereas haemoglobin or haptoglobin display no to low affinity toward CD163. Upon ligand binding, CD163 initiates signal transduction which leads to the production of IL-6 and IL-10. Furthermore, it has been demonstrated that cytokines such as IL-6 and IL-10 can induce expression of CD163, whereas proinflammatory stimuli, such as LPS or TNF alpha, can cause shedding of a soluble form of CD163, whose function is unclear.