CD163 Mouse anti-Human, PE, Clone: eBioGHI/61 (GHI/61), eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-1639-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15552163

Quantity Price
1 £ 54.42 / Pack of 25
EU Stock 3
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Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Regulatory Status RUO
Concentration 5μL (0.25μg)/test
Conjugate PE
Format Conjugated
Applications Flow Cytometry
Isotype IgG1
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Clone eBioGHI/61 (GHI/61)
Species Reactivity Human
Gene Alias M130, Hemoglobin Scavenger Receptor, Macrophage marker
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Host Species Mouse
Quantity 25 tests
Antigen CD163

The eBioGHI/61 monoclonal antibody reacts with human CD163 (Haemoglobin Scavenger Receptor, M130), a member of the macrophage scavenger receptor family. CD163 is expressed by tissue macrophages, circulating blood monocytes, and some reports suggest that it may also be expressed by haematopoietic progenitor cells. CD163 functions as a high affinity scavenger receptor for the complex of haemoglobin and haptoglobin which forms to clear haemoglobin from the blood. The high affinity for CD163 is specific for the haemoglobin-haptoglobin complex, whereas haemoglobin or haptoglobin display no to low affinity toward CD163. Upon ligand binding, CD163 initiates signal transduction which leads to the production of IL-6 and IL-10. Furthermore, it has been demonstrated that cytokines such as IL-6 and IL-10 can induce expression of CD163, whereas proinflammatory stimuli, such as LPS or TNF alpha, can cause shedding of a soluble form of CD163, whose function is unclear.