CD163 Mouse anti-Human, Clone: eBioGHI/61 (GHI/61), eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-1639-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15227267

Quantity Price
1 £ 42.19 / 25µg
Estimated Shipment date
from Supplier 05-04-2017
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Description and Specification

Specification

Species Reactivity Human
Concentration 0.5mg/mL
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Monoclonal or Polyclonal Monoclonal
Quantity 25μg
Primary or Secondary Primary
Applications Flow Cytometry
Applications Western Blotting
Storage Requirements Store at 2-8°C.
Isotype IgG1
Regulatory Status RUO
Host Species Mouse
Clone eBioGHI/61 (GHI/61)
Conjugate Unlabeled
Antigen CD163
Format Purified
Gene Alias M130, Haemoglobin Scavenger Receptor, Macrophage marker

The eBioGHI/61 monoclonal antibody reacts with human CD163 (Haemoglobin Scavenger Receptor, M130), a member of the macrophage scavenger receptor family. CD163 is expressed by tissue macrophages, circulating blood monocytes, and some reports suggest that it may also be expressed by haematopoietic progenitor cells. CD163 functions as a high affinity scavenger receptor for the complex of haemoglobin and haptoglobin which forms to clear haemoglobin from the blood. The high affinity for CD163 is specific for the haemoglobin-haptoglobin complex, whereas haemoglobin or haptoglobin display no to low affinity toward CD163. Upon ligand binding, CD163 initiates signal transduction which leads to the production of IL-6 and IL-10. Furthermore, it has been demonstrated that cytokines such as IL-6 and IL-10 can induce expression of CD163, whereas proinflammatory stimuli, such as LPS or TNF alpha, can cause shedding of a soluble form of CD163, whose function is unclear.