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CD163 Mouse anti-Human, APC, Clone: GHI/61, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-1639-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15518036

  • £170.44 / 100 tests


EU Stock 6
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Disclaimers:

For Research Use Only.


Description

Description

The eBioGHI/61 monoclonal antibody reacts with human CD163 (Haemoglobin Scavenger Receptor, M130), a member of the macrophage scavenger receptor family. CD163 is expressed by tissue macrophages, circulating blood monocytes, and some reports suggest that it may also be expressed by haematopoietic progenitor cells. CD163 functions as a high affinity scavenger receptor for the complex of haemoglobin and haptoglobin which forms to clear haemoglobin from the blood. The high affinity for CD163 is specific for the haemoglobin-haptoglobin complex, whereas haemoglobin or haptoglobin display no to low affinity toward CD163. Upon ligand binding, CD163 initiates signal transduction which leads to the production of IL-6 and IL-10. Furthermore, it has been demonstrated that cytokines such as IL-6 and IL-10 can induce expression of CD163, whereas proinflammatory stimuli, such as LPS or TNF alpha, can cause shedding of a soluble form of CD163, whose function is unclear.
Specifications

Specifications

CD163
eBioGHI/61 (GHI/61)
Allophycocyanin
Conjugated
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.5μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
M130, Hemoglobin Scavenger Receptor, Macrophage marker
IgG1
RUO
Primary
Human