CD162 (PSGL-1) Mouse anti-Human, PerCP-eFluor 710, Clone: FLEG, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-1629-41

Product Code. 15569196

Disclaimers:

For Research Use Only.

Description

This FLEG monoclonal antibody recognizes human CD162, which is also known as P-selectin glyocoprotein ligand-1 (PSGL-1). This 120kDa protein exists as a homodimer on the surface of monocytes, neutrophils, granulocytes, peripheral T cells, some B cells, and a subset of CD34+ hematopoietic progenitor cells (HPCs) in the bone marrow. CD162 binds CD62P (P-selectin), CD62E (E-selectin), and CD62L (L-selectin) to mediate leukocyte interactions with each other as well as with activated platelets and endothelium. Thus, CD162 plays a critical role in leukocyte adhesion and rolling. Furthermore, the binding of CD162 to P-selectin on HPCs has been demonstrated to inhibit hematopoiesis. Studies have also demonstrated CD162 as the receptor for enterovirus 71.

Specifications

• Antigen: CD162 (PSGL-1)
• Clone: FLEG
• Conjugate: PerCP-eFluor 710
• Format: Conjugated
• Isotype: IgG2a
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human

• Applications: Flow Cytometry
• Concentration: 5μL (0.06μg)/test
• Formulation: aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Host Species: Murine
• Quantity: 25 Tests
• Storage Requirements: Store at 2-8°C. Do not freeze. Light-sensitive material.
• Monoclonal or Polyclonal: Monoclonal